If you are already seeing signs of premature skin aging from years of fun in the sun, there may be help. Permanent skin changes such as darkened patches, age spots and fine lines are likely the result of accumulated sun exposure. Chronic UV exposure can damage melanocytes, the cells in the skin that are responsible for producing melanin (gives skin its colour). One form of sun damage involves the triggering of melanocytes to increase melanin production, which eventually leads to age spots, discoloured patches, and uneven skin tone. Glucosamine is a natural substance that is found in the joints of bones, and it is commonly ingested in the form of supplements to treat arthritis. Recent research indicates that glucosamine may prevent new signs of skin changes from occurring, and even fade existing blemishes by interrupting the chemical signals that promote melanin production. The more stable form of this compound is called n-acetyl glucosamine, which in combination with niacinamide (a form of vitamin B), may even out skin tone by slowing down the production of pigment in the skin.